Chromosome changes in a secondary lymphoma

A case of probable secondary lymphoma, poorly differentiated lymphocytic lymphoma (PDLL), is described in which two chromosomal translocations were observed, i.e., t(10;19)(q11;q13) and t(1;6)(q21;p11.1-2). A consistent numerical aberration was monosomy of chromosome #21. Accumulation of more data on secondary lymphomas is necessary in order to reach a general conclusion as to whether or not there are any nonrandom chromosomal aberrations that differentiate primary from secondary lymphomas.