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Updated: Jul 2, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

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Combinatorial biosynthesis in yeast leads to over 200 diterpenoids

Maximilian Frey1, Ulschan Bathe2, Luca Meink1

  • 1Department of Cell and Metabolic Biology, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany.

Metabolic Engineering
|February 22, 2024
PubMed
Summary

Combinatorial biosynthesis in yeast generated over 200 diterpenoids, with 162 new-to-Nature compounds. This approach expands the exploration of diverse diterpenoid chemical space for potential pharmaceuticals and industrial applications.

Keywords:
Combinatorial biosynthesisCytochrome P450 oxidasesDiterpenesGolden gate cloningNew-to-natureSynthetic biologyTerpene synthasesYeast

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