Related Experiment Video

Updated: May 7, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.7K

New Perspectives in Neuroprotection for Ischemic Stroke

María Pérez-Mato1, Esteban López-Arias1, Ana Bugallo-Casal1

  • 1Translational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.

Neuroscience
|February 22, 2024
PubMed

Insights

Despite past failures, new advances in understanding ischemic stroke and improved treatments like mechanical recanalization offer renewed hope for developing effective neuroprotective therapies.

Area of Science:

  • Neuroscience
  • Neurology
  • Pharmacology

Background:

  • Previous neuroprotective therapies for ischemic stroke have largely failed, increasing development risks.
  • Stroke is a complex condition with a narrow treatment window and comorbidities, hindering therapeutic progress.

Purpose of the Study:

  • To review current neuroprotective agents for ischemic stroke.
  • To analyze how recent advancements enhance neuroprotection efficacy.

Main Methods:

  • Literature review of neuroprotective agents.
  • Analysis of recanalization therapies, imaging, and biomarkers' impact on stroke treatment.

Main Results:

  • Several neuroprotective agents are in clinical evaluation.
  • Recanalization therapies, advanced imaging, and biomarkers show promise in improving stroke outcomes.

Conclusions:

  • Recent progress in stroke pathophysiology and treatment strategies creates new opportunities for neuroprotection research.
  • Combination of therapies and advanced diagnostics may improve the efficacy of neuroprotective treatments for ischemic stroke.
Keywords:
biomarkersearly diagnosisischemic strokeneuroprotectionrecanalization therapies

More Related Videos

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats10:15

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

8.3K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

2.0K

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
57
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
74
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
57