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New Perspectives in Neuroprotection for Ischemic Stroke

María Pérez-Mato1, Esteban López-Arias1, Ana Bugallo-Casal1

  • 1Translational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.

Neuroscience
|February 22, 2024
PubMed
Summary

Despite past failures, new advances in understanding ischemic stroke and improved treatments like mechanical recanalization offer renewed hope for developing effective neuroprotective therapies.

Keywords:
biomarkersearly diagnosisischemic strokeneuroprotectionrecanalization therapies

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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