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[Research Progress on the Mechanism of PI3K/AKT/mTOR Signaling Pathway in Multiple Myeloma --Review]

Qing-Qing Liu1, Yi-Qiang Li1, Wei-Min Cheng2

  • 1Graduate School of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|February 22, 2024
PubMed

Insights

Inhibiting the PI3K/AKT/mTOR pathway activates apoptosis and autophagy in multiple myeloma (MM) cells, promoting cell death and hindering metastasis. This highlights the pathway's crucial role in MM pathogenesis and prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Context:

  • The PI3K/AKT/mTOR signaling pathway is implicated in various cancers, including multiple myeloma (MM).
  • This pathway regulates critical cellular processes such as proliferation, apoptosis, and autophagy.
  • Its dysregulation is closely linked to the pathogenesis and progression of MM.

Purpose:

  • To elucidate the multifaceted role of the PI3K/AKT/mTOR signaling pathway in multiple myeloma.
  • To investigate how inhibiting this pathway affects MM cell behavior and survival.

Summary:

  • The PI3K/AKT/mTOR pathway influences MM by modulating the tumor microenvironment, cell survival, migration, proliferation, apoptosis, and autophagy.
  • Inhibition of this pathway has been shown to activate apoptosis and autophagy in MM cells.
  • This activation promotes MM cell death and suppresses metastasis and recurrence.

Impact:

  • Understanding the PI3K/AKT/mTOR pathway's mechanism in MM is vital for developing targeted therapies.
  • Inhibiting this pathway offers a potential therapeutic strategy to combat MM progression.
  • This research contributes to elucidating the pathogenesis and improving the prognosis of multiple myeloma.
Keywords:
PI3K/AKT/mTORmechanism of actionmultiple myeloma

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