Related Experiment Video

Updated: Jul 2, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

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[Research Progress of Long Non-Coding RNA in Multiple Myeloma--Review]

Shu-E Cun1, Jiang-Ting Zheng1, Yu-Ming Wang2

  • 1Department of Clinical Laboratory Examination, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|February 22, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate gene expression and are implicated in multiple myeloma (MM) development and drug resistance. Understanding lncRNA roles offers new diagnostic and therapeutic strategies for MM.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Context:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
  • Aberrant lncRNA expression is increasingly linked to various diseases.
  • Multiple myeloma (MM) is a hematological malignancy with complex regulatory mechanisms.

Purpose:

  • To investigate the role and molecular mechanisms of dysregulated lncRNAs in multiple myeloma (MM).
  • To explore how lncRNAs influence the occurrence, progression, and drug resistance of MM.
  • To identify potential lncRNA biomarkers for MM diagnosis and targeted therapy.

Summary:

  • lncRNAs can modulate disease development by regulating target genes and signaling pathways.
  • Numerous lncRNAs have been identified to play roles in the pathogenesis and drug resistance of MM.
  • Studying abnormal lncRNA expression in MM is crucial for understanding disease mechanisms.

Impact:

  • Provides a theoretical foundation for the clinical diagnosis of multiple myeloma.
  • Highlights the potential of lncRNAs as targets for novel therapeutic interventions in MM.
  • Advances the understanding of molecular mechanisms underlying MM development and treatment resistance.
Keywords:
multiple myelomadrug resistancelong non-coding RNA

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