Related Experiment Video
Updated: Jun 29, 2026
Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
Published on: February 15, 2022
[Research status and reflection on animal models of sepsis]
1Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine,Hangzhou 310052, China.
Insights
Sepsis, a critical infectious disease, causes many child deaths globally. This review examines animal models for sepsis diagnosis and treatment, aiming to improve patient outcomes and clinical practice.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Context:
- Sepsis is a leading cause of mortality in children worldwide.
- Early diagnosis and intervention are crucial for improving sepsis patient prognosis.
- Existing animal models are vital for understanding and combating pediatric sepsis.
Purpose:
- To review and analyze current animal models for sepsis.
- To identify the advantages and disadvantages of existing sepsis models.
- To propose optimizations for sepsis animal models to aid clinical translation.
Summary:
- This study provides a comprehensive review of animal models used in sepsis research.
- It evaluates the strengths and limitations of various sepsis models.
- Recommendations are made for optimizing these models to better reflect human sepsis and improve clinical outcomes.
Impact:
- Enhances the selection and optimization of experimental sepsis models.
- Facilitates the translation of sepsis research findings into clinical practice.
- Aims to reduce the global burden of childhood sepsis through improved research models.
Abstract:
Infectious diseases are the leading cause of death in children. Sepsis is a critical infectious disease that causes death in children globally, with a high morbidity and mortality rate. It poses a serious threat to children's health. Early diagnosis has become the key to treating severe sepsis. The establishment of animal models of sepsis can help people better diagnose sepsis and take interventions to improve the prognosis of sepsis patients. This study reviews the types, advantages and disadvantages of existing animal models of sepsis and proposes the optimization of these models to provide a reference basis for the selection and optimization of experimental models and the promotion of the "reverse transformation" of sepsis into clinical practice.
