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[Research progress on influencing factors of allergic rhinitis in children]
Insights
Allergic rhinitis (AR) is rising in children, impacting their development and causing societal burdens. This study examines individual and external factors contributing to childhood AR for better prevention and treatment strategies.
Area of Science:
- Pediatrics
- Immunology
- Environmental Health
Context:
- Allergic rhinitis (AR) incidence is increasing globally, particularly in pediatric populations.
- Childhood AR significantly affects development, learning, and quality of life, imposing substantial socioeconomic burdens.
- Understanding the multifactorial nature of AR is crucial for effective management.
Purpose:
- To explore the influence of individual factors (genetic polymorphisms, epigenetics, inflammation, microecology) on pediatric AR.
- To review the impact of external factors (allergens, air pollution, infections, climate change) on childhood AR.
- To enhance the understanding of pediatric AR and establish a foundation for prevention and treatment.
Summary:
- Investigates individual factors including genetic predispositions, epigenetic modifications, inflammatory pathways, and gut microbiome alterations in pediatric allergic rhinitis.
- Examines environmental triggers such as aeroallergens, air pollutants, infectious agents, immune system dynamics, and climatic variations contributing to AR.
- Synthesizes current knowledge on the complex interplay of intrinsic and extrinsic elements driving the rise of AR in children.
Impact:
- Provides a comprehensive overview of pediatric AR etiology, aiding clinicians and researchers.
- Offers insights into potential targets for novel therapeutic interventions and preventative measures.
- Contributes to public health strategies aimed at mitigating the growing burden of allergic rhinitis in children.
Abstract:
The incidence of allergic rhinitis (AR) is increasing year by year, especially in children. AR not only affects the growth, development, life and learning of children but also causes huge economic and social burdens. This study explores the impact of individual factors such as genetic polymorphisms, epigenetics, inflammatory response mechanisms, and microecological influence mechanisms on children's AR. It also reviews the impact of external factors such as allergenic factors, ambient air pollutants, infection and immunity factors, and climate and climate change on the disease, with the aim of improving understanding of AR in children and providing a basis for its prevention and treatment.
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