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Paediatric norms for photopic electroretinogram testing based on a large cohort of Chinese preschool children

Sonia Seen-Hang Chan1, Kai Yip Choi1, Henry Ho-Lung Chan2,3,4

  • 1Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.

BMJ Open Ophthalmology
|February 22, 2024
PubMed

Insights

This study established a reference dataset for photopic electroretinograms (ERG) in Hong Kong Chinese preschool children. Findings reveal associations between ERG parameters, age, and axial length, aiding in understanding retinal development and refractive error.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pediatric Medicine

Background:

  • Full-field electroretinogram (ffERG) is crucial for assessing retinal function and diagnosing diseases.
  • Establishing normative data is essential for accurate clinical interpretation and research.

Purpose of the Study:

  • To create a reference dataset for photopic ffERG in Chinese preschool children (3-7 years) in Hong Kong.
  • To investigate the relationships between ERG parameters, age, and ocular measurements (SER, AL, K).

Main Methods:

  • Recruited 479 preschool children with normal vision.
  • Performed eye examinations including SER, AL, and K measurements.
  • Recorded ffERGs using ISCEV standard photopic flash and 30-Hz flicker protocols with RETeval and skin electrodes.

Main Results:

  • Established mean values, CIs, and percentile ranges for ERG parameters.
  • Found positive associations between age and b-wave/30-Hz flicker amplitudes, and negative associations with their implicit times.
  • Identified significant associations between axial length and various ERG amplitudes and implicit times; keratometry showed a positive association with 30-Hz flicker amplitude.

Conclusions:

  • A reference dataset for photopic ERG in Chinese preschool children was successfully established.
  • Cross-sectional analysis revealed significant associations between ERG, age, and axial length.
  • These findings may offer insights into the retina's role in refractive error development.
Abstract

Keywords:
Child health (paediatrics)ElectrophysiologyOptics and RefractionRetina

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