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Published on: November 29, 2024
Exploring nontraditional cardiorenal advantages of SGLT-2 inhibitors and GLP-1 receptor agonists
Jia-Jin Chen1, Tao-Han Lee2, Huang-Yu Yang3
1Kidney Research Center, Nephrology Department, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Abstract:
This commentary provides an analysis of the study by Fu et al. in Kidney International, which employs 3 administrative databases to investigate the hyperkalemia protective effects of sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase-4 inhibitors. It emphasizes the methodological approach, notably the use of a fixed-effect model to aggregate pairwise comparisons from 3 data sets. In addition, we explored the broader cardiorenal and potential nonrenal benefits of these drug classes, underscoring the imperative for continued research in this domain.
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