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Related Concept Videos

  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Veterinary Sciences
  9. Veterinary Medicine (excl. Urology)
  11. Urinary And Household Chemical Exposures In Pet Dogs With Urothelial Cell Carcinoma.
  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Veterinary Sciences
  9. Veterinary Medicine (excl. Urology)
  11. Urinary And Household Chemical Exposures In Pet Dogs With Urothelial Cell Carcinoma.

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Urinary and household chemical exposures in pet dogs with urothelial cell carcinoma.

Samantha L Braman1, Hannah Peterson1, Amy Elbe1

  • 1Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Veterinary and Comparative Oncology
|February 22, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Household chemical exposures, like swimming pool use and drinking water contaminants, may increase urothelial cell carcinoma (UCC) risk in pet dogs. Owners should consider water filtration and limiting pool access for at-risk breeds.

Keywords:
bladder cancercanineenvironmental riskswimming pool

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Area of Science:

  • Veterinary Medicine
  • Environmental Toxicology
  • Canine Oncology

Background:

  • Urothelial cell carcinoma (UCC) in dogs is suspected to be linked to environmental chemical exposures, similar to human cases.
  • However, specific risk factors for UCC in pet dogs remain poorly understood.
  • This study investigates household chemical exposures as potential contributors to UCC risk in canines.

Purpose of the Study:

  • To identify potential household chemical risk factors for urothelial cell carcinoma (UCC) in pet dogs.
  • To compare environmental exposures between dogs diagnosed with UCC and healthy controls.
  • To provide recommendations for pet owners to mitigate UCC risk.

Main Methods:

  • A prospective cross-sectional case-control study involving 37 dogs with UCC and 37 matched controls.
total trihalomethanes
transitional cell carcinoma
  • Owners completed environmental questionnaires; household samples (tap water, dust, air) were analyzed for arsenic and acrolein.
  • Urine samples were tested for arsenic metabolites, acrolein metabolite (3-HPMA), and 2,4-D herbicide; municipal water data on disinfection byproducts were also assessed.

    • Main Results:

    • Dogs with UCC were more likely to swim in pools (15.2% vs. 0%) compared to controls.
    • UCC cases had significantly higher municipal drinking water concentrations of chlorination byproducts (total trihalomethanes) than controls (median 28.0 ppb vs. 6.9 ppb).
    • Arsenic concentrations in household dust were unexpectedly lower in case households than in control households.

    Conclusions:

    • Exposure to swimming pools and higher concentrations of chlorination byproducts in drinking water may be risk factors for canine urothelial cell carcinoma (UCC).
    • Dog owners, particularly those with breeds predisposed to UCC, should consider limiting pool access and using water filtration systems targeting total trihalomethanes.
    • Further research is needed to elucidate the complex relationship between environmental chemicals and UCC development in dogs.