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Association between sinusitis and incident rheumatic diseases: a population-based study
Vanessa L Kronzer1, John M Davis2, Andrew C Hanson3
1Mayo Clinic, Rochester, Minnesota, USA kronzer.vanessa@mayo.edu.
RMD Open
|February 22, 2024
Summary
Antecedent sinusitis significantly increases the risk of developing various rheumatic diseases, including antiphospholipid syndrome and Sjögren's disease. This suggests sinus inflammation may play a role in the development of these conditions.
Area of Science:
- Rheumatology
- Immunology
- Otolaryngology
Background:
- Rheumatic diseases encompass a group of autoimmune and inflammatory conditions affecting joints, muscles, and connective tissues.
- The etiology of many rheumatic diseases remains incompletely understood, with potential environmental triggers being investigated.
- Sinusitis, an inflammation of the sinuses, is a common condition with potential systemic implications.
Purpose of the Study:
- To investigate the association between a history of sinusitis and the subsequent development of various rheumatic diseases.
- To determine if sinusitis is a potential risk factor or predictor for incident rheumatic conditions.
Main Methods:
- A population-based case-control study design was employed, including individuals diagnosed with rheumatic diseases between 1995 and 2014.
- Three controls were matched to each case based on age, sex, and duration of electronic health record history.
- Sinusitis was identified using diagnosis codes, and logistic regression models were used to calculate odds ratios (ORs) for rheumatic disease incidence, adjusted for confounders.
Main Results:
- The study identified 1729 incident rheumatic disease cases and 5187 controls.
- Preceding sinusitis was linked to an elevated risk of antiphospholipid syndrome (OR 7.0), Sjögren's disease (OR 2.4), vasculitis (OR 1.4), and polymyalgia rheumatica (OR 1.4).
- Acute sinusitis was associated with an increased risk of seronegative rheumatoid arthritis (OR 1.8), and the association was strongest in the 5-10 years prior to disease onset and in never-smokers.
Conclusions:
- A history of sinusitis is associated with an increased incidence of several rheumatic diseases.
- These findings suggest that sinus inflammation may contribute to the pathogenesis of rheumatic diseases.
- Further research is warranted to explore the biological mechanisms linking sinusitis and rheumatic disease development.
Keywords:
Antiphospholipid SyndromeArthritis, RheumatoidAutoimmune DiseasesEpidemiologySjogren's SyndromeMore Related Videos
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