The potential role of the triglyceride-glucose index in left ventricular systolic function and in-hospital outcomes...

Area of Science:

• Cardiology
• Metabolic Syndrome Research
• Clinical Risk Stratification

Background:

• Limited research exists on the triglyceride-glucose index (TGI) and in-hospital prognosis in acute myocardial infarction (AMI).
• The combined predictive value of TGI and left ventricular ejection fraction (LVEF) for major adverse cardiovascular events (MACE) in AMI patients is not well understood.

Purpose of the Study:

• To investigate the association between TGI and LVEF in patients with AMI.
• To determine the role of TGI and LVEF in predicting in-hospital MACE in AMI patients.

Main Methods:

• Analysis of data from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) project.
• Inclusion of 43,796 patients diagnosed with AMI.
• Statistical analysis including interaction and risk stratification.

Main Results:

• Higher TGI was significantly associated with increased risk of MACE (aOR 1.46; 95% CI 1.31-1.63).
• LVEF significantly modified the relationship between TGI and MACE.
• The group with low LVEF and high TGI exhibited the highest MACE risk (aOR 2.14; 95% CI 1.58-2.89).

Conclusions:

• Elevated TGI is linked to in-hospital MACE in AMI patients, especially those with reduced LVEF.
• The combination of TGI and LVEF provides a valuable tool for risk stratification in AMI patients.