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Updated: Jul 2, 2025

High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode

High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode

Published on: January 11, 2011

An Open-Source Mouse Chronic EEG Array System with High-Density MXene-Based Skull Surface Electrodes.

Li Ding¹, Aashvi Patel¹, Sneha Shankar²

¹Department of Neurology, Vanderbilt University School of Medicine, Nashville 37232, Tennessee.

|February 22, 2024

Summary

This summary is machine-generated.

Researchers developed a novel, cost-effective method for mouse electroencephalography (EEG) using flexible MXene electrodes placed on the skull. This technique simplifies recordings, reduces surgery, and reveals new insights into traumatic brain injury.

Keywords:

GABAA computer-assisted electrodes electrophysiology epilepsy mild traumatic brain injury receptors signal processing

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Last Updated: Jul 2, 2025

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Published on: January 11, 2011

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources

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Published on: May 26, 2023

Area of Science:

Neuroscience
Materials Science
Biomedical Engineering

Background:

Traditional intracranial electroencephalography (EEG) in rodents requires invasive surgery, is time-consuming, and limits electrode number.
Existing methods can confound studies, particularly those involving traumatic brain injury (TBI).

Purpose of the Study:

To develop an open-source, cost-effective, and less invasive method for chronic mouse EEG recording.
To utilize a novel 2D nanomaterial, titanium carbide (Ti3C2Tx) MXene, for electrode fabrication.

Main Methods:

Fabrication of two-channel (EEG2) and sixteen-channel high-density EEG (HdEEG) arrays using MXene electrodes.
Non-invasive placement of MXene electrodes on the intact mouse skull, eliminating the need for conductive gel.
Application of HdEEG in a mild traumatic brain injury (mTBI) model in mice.

Main Results:

MXene electrodes significantly reduce fabrication and implantation times compared to traditional methods.
Recorded EEG waveforms (baseline and epileptiform) are comparable to those from conventional epidural electrodes.
mTBI significantly increased preictal network connectivity in the β-spectral band (12-30 Hz) associated with spike-wave discharges (SWDs).

Conclusions:

MXene electrode arrays offer a cost-effective, efficient, and minimally invasive technology for multichannel EEG recording in mice.
This technique obviates the need for skull-penetrating surgery, simplifying experimental procedures.
Increased preictal β-frequency network connectivity may be a biomarker for early post-mTBI SWDs.