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Generalising XTRACT tractography protocols across common macaque brain templates.

Stephania Assimopoulos1, Shaun Warrington1, Katherine L Bryant2,3

  • 1Sir Peter Mansfield Imaging Centre, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK.

Brain Structure & Function
|February 22, 2024
PubMed
Summary

This study generalizes tractography protocols (XTRACT) for macaque brain templates, ensuring consistent white matter (WM) bundle reconstruction across diverse models. Results confirm protocol equivalence, validating their use with multiple macaque brain templates in neuroscience research.

Keywords:
Comparative anatomyConnectivityDiffusion MRIF99INIANHPNMTYerkes19

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Area of Science:

  • Neuroscience
  • Comparative Anatomy
  • Medical Imaging

Background:

  • Non-human primates, particularly rhesus macaques, are crucial models in neuroscience research for understanding the human brain.
  • Previous tractography protocols (XTRACT) enabled reconstruction and cross-species comparison of 42 white matter (WM) bundles between human and macaque brains using the F99 template.

Purpose of the Study:

  • To generalize existing XTRACT tractography protocols to five different macaque brain templates (F99, D99, INIA, Yerkes, NMT).
  • To validate the cross-species comparability of reconstructed white matter bundles across these templates.

Main Methods:

  • Defined XTRACT protocol generalisations for five macaque brain templates.
  • Compared tract bodies derived from protocols across different templates.
  • Assessed cross-species (human-macaque) projection patterns using reconstructed tracts from each template.

Main Results:

  • Tractography protocols demonstrated equivalence across all five macaque brain templates.
  • Comparison of tract bodies and projection patterns showed high similarity regardless of the template used.
  • Reconstructed white matter bundles were consistent across the F99, D99, INIA, Yerkes, and NMT templates.

Conclusions:

  • The generalized XTRACT protocols are robust and applicable across multiple macaque brain templates.
  • This generalisability ensures reliable cross-species comparisons in neuroscience research.
  • The findings provide strong evidence for the wide applicability of these tractography protocols.