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Fluorinated GlycoNucleoLipid-based hydrogels as new spatiotemporal stimulable DDS
Alexandra Gaubert1, Thibault Castagnet2, Jevon Marsh2
1University of Bordeaux, ARNA laboratory, INSERM U1212, UMR CNRS 5320, F-33076, Bordeaux, France. alexandra.gaubert@u-bordeaux.fr.
Drug Delivery and Translational Research
|February 22, 2024
Summary
This study introduces novel supramolecular hydrogels for controlled drug delivery, enhancing cancer treatment by combining doxorubicin and phenazine 14. These gels offer tunable stiffness and triggered release, improving therapeutic potential.
Area of Science:
- Materials Science
- Biomedical Engineering
- Pharmaceutical Sciences
Background:
- Controlled release of active pharmaceutical ingredients (APIs) is crucial for enhancing therapeutic efficacy and minimizing side effects.
- Developing advanced drug delivery systems (DDS) capable of responding to stimuli is a key challenge in modern medicine.
Purpose of the Study:
- To design and characterize novel stimulable drug delivery systems (DDS) based on supramolecular hydrogels.
- To investigate the loading and release of two anticancer drugs, doxorubicin (Doxo) and phenazine 14 (Phe), within these hydrogels.
- To evaluate the physicochemical properties and mechanical responses of the drug-loaded hydrogels.
Main Methods:
- Synthesis of Fluorinated GlycoNucleoLipid (GNF) based supramolecular hydrogels.
- In vitro loading and stability studies of doxorubicin and phenazine 14 within the GNF gels.
- Rheological measurements to assess gel stiffness (storage modulus G') and thixotropic properties.
- In vitro drug release studies under varying mechanical stimulation conditions.
Main Results:
- GNF-based supramolecular hydrogels demonstrated stability in the presence of both doxorubicin and phenazine 14.
- Loading of both APIs significantly enhanced gel stiffness, increasing the storage modulus from 1.3 kPa to 9.3 kPa, while preserving thixotropic behavior.
- Passive diffusion resulted in doxorubicin release, while phenazine 14 remained entrapped under low mechanical stimulation.
- Mechanical stress was shown to trigger the differential release of both phenazine 14 and doxorubicin from the hydrogels.
Conclusions:
- Fluorinated GlycoNucleoLipid (GNF) supramolecular hydrogels represent a promising platform for developing advanced, stimulable drug delivery systems.
- The tunable mechanical properties and triggered release capabilities of these hydrogels offer potential for improved anticancer therapy.
- Further research into these hydrogels could lead to more effective and targeted treatments with reduced side effects.
