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Understanding implementation of findings from trial method research: a mixed methods study applying implementation

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  • 1Health Services Research Unit, University of Aberdeen, Health Services Research Unit, Foresterhill, Aberdeen, AB25 2ZD, UK. taylor.coffey1@abdn.ac.uk.

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Implementing trial method research is challenging due to resource limitations and lack of awareness. Strategies to improve implementation involve leveraging trial networks and providing packaged resources for clinical trial units.

Keywords:
Implementation scienceTrial method research

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Area of Science:

  • Clinical Trials
  • Implementation Science
  • Health Services Research

Background:

  • Trial method research generates best practice recommendations for conducting clinical trials.
  • These recommendations are often not implemented into routine practice.
  • Understanding implementation challenges is crucial for improving trial quality.

Purpose of the Study:

  • To investigate the obstacles and facilitators to implementing trial method research findings in UK clinical trial units.
  • To identify potential strategies for enhancing the adoption of research recommendations.

Main Methods:

  • A mixed-methods study involving case studies, surveys, and semi-structured interviews.
  • Survey data collected from 27 UK trial units using the Consolidated Framework for Implementation Research.
  • Interviews with 16 senior trial unit members, analyzed using the Capability, Opportunity, Motivation Model of Behaviour.

Main Results:

  • Implementation rates varied, with higher adoption for trial conduct recommendations and lower for reporting.
  • Key obstacles included resource limitations and lack of awareness.
  • Facilitators included participation in trial networks and resource-accompanied recommendations.

Conclusions:

  • Resource constraints and awareness are significant barriers to implementing trial method research.
  • Leveraging trial networks and providing tailored resources can enhance implementation.
  • Further research is needed to develop and test practical implementation strategies.