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EMCDDA framework and practical guidance for naming cathinones.

Benedikt Pulver1,2, Svenja Fischmann1, Ana Gallegos3

  • 1State Bureau of Criminal Investigation Schleswig-Holstein, Forensic Science Institute, Kiel, Germany.

Drug Testing and Analysis
|February 23, 2024
PubMed
Summary
This summary is machine-generated.

A new naming framework for cathinones, a major group of new psychoactive substances (NPS), has been developed. This system ensures consistent and understandable nomenclature for researchers, forensic experts, and policymakers.

Keywords:
NPScathinonesearly warning systemharmonizationsemi‐systematic naming

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Area of Science:

  • Forensic Chemistry
  • Pharmacology
  • Drug Policy

Background:

  • Cathinones are frequently marketed as legal substitutes for controlled stimulants like amphetamines and cocaine.
  • Representing the second-largest category of new psychoactive substances (NPS), nearly 170 cathinones are monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).
  • Inconsistent and varied naming conventions for cathinones complicate identification and regulation.

Purpose of the Study:

  • To establish a clear, consistent, and user-friendly naming framework for cathinones.
  • To provide practical examples for applying the proposed nomenclature.
  • To address the challenges posed by the diverse and evolving landscape of cathinone substances.

Main Methods:

  • Development of a naming framework based on established nomenclature principles, focusing on "cathinone" and "phenone" scaffolds.
  • Establishment of clear rules for deriving names, including a principal name and appended substitutions.
  • Consideration of exceptions for cathinones and structural analogs regulated under international and EU legislation.

Main Results:

  • A proposed framework for the consistent naming of cathinones has been developed.
  • The framework utilizes "cathinone" and "phenone" as core structural motifs.
  • Clear rules are provided for deriving names, accommodating substitutions and legislative exceptions.

Conclusions:

  • The proposed naming framework offers a standardized approach for identifying and discussing cathinones.
  • This consistency is crucial for effective monitoring, research, and policy-making concerning new psychoactive substances.
  • The framework aims to improve communication and understanding among forensic scientists, clinicians, researchers, and policymakers.