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Autonomic Nervous System Dysfunction in Achalasia.

Min-Jae Kim1, Eunha Cho1, Zahid Hussain1

  • 1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|February 23, 2024
PubMed
Summary
This summary is machine-generated.

Autonomic nervous system (ANS) dysfunction is common in achalasia patients, particularly females. These patients exhibit increased cardiac activity, suggesting a need for closer cardiac monitoring.

Keywords:
Autonomic nervous systemEsophageal achalasiaHeart rate

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Area of Science:

  • Gastroenterology
  • Neurology
  • Cardiology

Background:

  • Achalasia is an esophageal motility disorder causing dysphagia and chest pain.
  • Vagal nerve impairment is suspected in achalasia.
  • This study investigates autonomic nervous system (ANS) dysfunction in achalasia patients.

Purpose of the Study:

  • To evaluate autonomic nervous system (ANS) dysfunctions in achalasia patients.
  • To correlate ANS dysfunction with clinical symptoms of achalasia.

Main Methods:

  • Prospective enrollment of 19 achalasia patients and 10 healthy controls.
  • Administration of an ANS dysfunction symptom questionnaire.
  • Performance of heart rate variability (HRV) testing.

Main Results:

  • 69% of achalasia patients reported ANS dysfunction symptoms, versus 30% of controls.
  • Achalasia patients with ANS dysfunction showed higher cardiac activity and stress endurance.
  • Female achalasia patients exhibited significantly higher cardiac activity compared to controls.

Conclusions:

  • ANS dysfunction symptoms are prevalent in achalasia.
  • Increased cardiac activity is observed in female achalasia patients and those with ANS dysfunction.
  • Consider cardiac overload in female achalasia patients or those with ANS dysfunction symptoms.