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Related Experiment Videos

Intrathecal orgotein.

K Lund-Olesen

    International Journal of Clinical Pharmacology Research
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Intrathecal injections of superoxide dismutase (SOD) showed potential benefits for multiple sclerosis patients, with many seeking further treatment. Lower SOD levels were observed in patients

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    Area of Science:

    • Neurology
    • Biochemistry

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Superoxide dismutase (SOD) is an enzyme with antioxidant properties.

    Purpose of the Study:

    • To evaluate the efficacy of intrathecal orgotein (a form of SOD) in patients with multiple sclerosis.
    • To assess the levels of orgotein in cerebrospinal fluid (CSF) of MS patients.

    Main Methods:

    • 133 intrathecal injections of orgotein were administered to patients between 1971-78.
    • Patient outcomes and requests for further treatment were recorded.
    • Orgotein levels in CSF samples from 16 MS patients were determined.

    Main Results:

    • A subjective impression of improvement was noted in MS patients receiving orgotein.

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  • 45% of 58 MS patients requested additional intrathecal injections.
  • One patient experienced relief from allergic headaches post-myelography.
  • Orgotein levels in the CSF of MS patients were found to be significantly lower than previously reported.

    • Conclusions:

    • Intrathecal orgotein may offer symptomatic relief for some multiple sclerosis patients.
    • Further research is needed to understand the role of SOD levels in MS pathogenesis and treatment.