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Updated: May 6, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
[Herpes simplex factors: Literature review]
Lisette Begazo1, Alysson Morante1, Carlos Espinoza Montes1
1Carrera de Estomatología, Facultad de Ciencias de la Vida y Salud. Universidad Científica del Sur, Lima, Perú. 100062307@cientifica.edu.pe, 100063806@ucientifica.edu.pe, cespinozam@cientifica.edu.pe Universidad Científica del Sur Carrera de Estomatología Facultad de Ciencias de la Vida y Salud Universidad Científica del Sur Lima Peru 100062307@cientifica.edu.pe 100063806@ucientifica.edu.pe cespinozam@cientifica.edu.pe.
Herpes simplex virus (HSV) can reactivate due to immunosuppression, stress, sun exposure, and infection in pregnancy. Understanding these triggers is crucial for managing HSV reactivation and potential complications.
Area of Science:
- Virology
- Immunology
Context:
- Herpes simplex virus (HSV) establishes lifelong latency in neural ganglia after initial infection.
- Reactivation of latent HSV can occur unpredictably, influenced by various host and environmental factors.
Purpose:
- To review and synthesize current scientific literature on factors predisposing to herpes simplex virus reactivation.
- To provide an updated overview of triggers for HSV recurrence.
Summary:
- A literature review identified key reactivation factors: immunosuppression (e.g., chemotherapy, immunosuppressant drugs), psychological stress, ultraviolet (UV) radiation from sun exposure, and maternal infection during pregnancy.
- Immunosuppression and stress hormones can mediate HSV reactivation. Sun exposure triggers reactivation in neurons, while maternal HSV infection poses risks to the fetus and delivery.
Impact:
- Informed clinical management of HSV infections.
- Enhanced understanding of HSV pathogenesis and recurrence triggers.
- Potential for developing targeted preventative strategies against HSV reactivation.
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