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Elastic Strain Energy for Shearing Stresses01:20

Elastic Strain Energy for Shearing Stresses

186
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
186
Elastic Strain Energy for Normal Stresses01:22

Elastic Strain Energy for Normal Stresses

158
Strain energy quantifies the energy stored within a material due to deformation under loading conditions, a fundamental concept in materials science and engineering. The strain energy can be modeled when a material is subjected to axial loading with uniformly distributed stress. In this scenario, the stress experienced by the material is the internal force divided by the cross-sectional area, and the strain induced is directly proportional to this stress through the modulus of elasticity.
If...
158
Dynamic Modulus of Elasticity of Concrete01:16

Dynamic Modulus of Elasticity of Concrete

331
The dynamic modulus of elasticity assesses how a concrete structure deforms under impact or dynamic loads. It is typically higher than the static modulus of elasticity, measured under slow, steady loading conditions.
The sonic test is a common method to determine the dynamic modulus. In this test, a concrete beam, sized either 6 x 6 x 30 inches or 4 x 4 x 20 inches, is clamped at its center. Vibrations are initiated at one end of the beam by an electromagnetic exciter unit powered by...
331
Bending and Torsional Moments01:20

Bending and Torsional Moments

3.7K
Bending and torsional moments are two fundamental concepts in structural engineering. They play an important role in understanding the behavior of materials and structures under different loading conditions.
The reaction developed in a structural element when subjected to an external force causes the element to bend. When a structural element bends upwards, it creates compressive normal forces on the top and tensile normal forces on the bottom, resulting in a couple that determines the bending...
3.7K
Castigliano's Theorem01:18

Castigliano's Theorem

401
Castigliano's theorem analyzes displacements and rotations in elastic structures. It relates the derivative of elastic strain energy to the applied forces or moments, allowing for the calculation of deformations. The theorem states that the partial derivative of the total strain energy of a system with respect to a specific load results in the displacement at the point where the load is applied. This principle applies to both forces and moments.
401
Pressure Variation in a Fluid at Rest01:11

Pressure Variation in a Fluid at Rest

255
In a fluid at rest, the pressure at any point beneath the fluid surface depends solely on the depth, not on the container's shape or size. This principle, known as hydrostatic pressure, arises because, in stationary fluids, there is no acceleration, meaning the forces within the fluid balance out. Only vertical forces, caused by the weight of the fluid above, contribute to pressure changes with depth.
When measuring pressure at two different levels within the fluid, the difference in...
255

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Related Experiment Video

Updated: Jul 2, 2025

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
09:06

Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing

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Proposing a Caputo-Land System for active tension. Capturing variable viscoelasticity.

Afnan Elhamshari1, Khalil Elkhodary2

  • 1The Robotics, Control, and Smart Systems Program, The American University in Cairo, 11835, New Cairo, Egypt.

Heliyon
|February 23, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a new fractional order system for modeling cardiomyocyte active tension, improving accuracy by accounting for viscoelasticity and individual patient variations. The enhanced model offers greater clinical relevance for disease diagnostics and drug screening.

Keywords:
Active tensionCaputo's fractional derivativesFractional-order systemsMean square error (MSE)Quick stretch and release experimentsVariable cardiac viscoelasticity

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Area of Science:

  • Cardiovascular Physiology
  • Biophysics
  • Computational Biology

Background:

  • Accurate cell-level active tension modeling is crucial for understanding cardiac function and disease.
  • Existing models lack viscoelasticity and inter-subject variability, limiting clinical applications like disease diagnostics and drug screening.

Purpose of the Study:

  • To propose a novel fractional order system for cell-level active tension modeling in cardiomyocytes.
  • To incorporate viscoelasticity and subject-specific variations into cardiac contraction models.

Main Methods:

  • Extended Land's model of cardiac contraction using a fractional order system.
  • Incorporated the (left) Caputo derivative of six state variables to represent mechanistic origins of viscoelasticity.
  • Validated the model against cell-level experimental data across multiple subjects.

Main Results:

  • The proposed model demonstrated notable subject-specificity.
  • Achieved smaller mean square errors compared to the reference model in cell-level experiments.
  • Successfully identified contributions of cellular mechanisms to viscoelastic behavior.

Conclusions:

  • The fractional order system provides a more accurate and clinically relevant model for cardiomyocyte active tension.
  • The model's ability to capture subject-specificity and viscoelasticity aids in understanding disease variations and drug effects.
  • This approach offers enhanced potential for disease diagnostics and cardiotoxicity screening.