Quantification of oxygen consumption in head and neck cancer using fluorescent sensor foil technology
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View abstract on PubMed
Summary
This summary is machine-generated.Quantifying oxygen consumption (OC) with fluorescent sensor foils can differentiate head and neck squamous cell carcinoma (HNSCC) from normal tissue. This technology aids in detecting residual tumor and planning surgeries for better patient outcomes.
Area Of Science
- Biomedical Engineering
- Oncology
- Medical Diagnostics
Background
- Head and neck squamous cell carcinoma (HNSCC) frequently recurs locally, impacting patient prognosis.
- Accurate differentiation between tumor and normal tissue is crucial for surgical planning and detecting residual disease.
Purpose Of The Study
- To evaluate a fluorescent sensor foil-based technology for quantifying oxygen consumption (OC) in HNSCC.
- To assess the potential of OC measurement for distinguishing tumor from normal tissue in head and neck cancers.
Main Methods
- <i>In vitro</i> 3D models using HNSCC cell lines and cancer-associated fibroblasts in collagen matrix.
- <i>In situ</i> measurements using a handheld device with sensor foils and oxygen-reactive fluorescent dyes on patients undergoing surgery for tongue and floor of mouth carcinomas.
Main Results
- <i>In vitro</i> detection of tumor cell spheroids down to 440 µm.
- <i>In situ</i> measurements showed significantly higher OC in tumor tissue compared to adjacent healthy mucosa.
- The technology demonstrated feasibility for pre-surgery assessment.
Conclusions
- Oxygen consumption quantification using fluorescent sensor foil technology is a viable method for differentiating HNSCC from normal tissue.
- This approach may enhance surgical planning and improve the detection of residual tumor in head and neck cancer patients.
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