Related Experiment Video

Updated: Jul 2, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

991

Targeting MYC at the intersection between cancer metabolism and oncoimmunology

Simran Venkatraman1, Brinda Balasubramanian2, Chanitra Thuwajit3

  • 1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

Frontiers in Immunology
|February 23, 2024
PubMed

Insights

MYC activation drives cancer by altering metabolism and immunity. This review explores MYC

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • MYC activation is a critical driver of cancer progression.
  • MYC influences both cancer metabolism (oncometabolism) and immune responses (oncoimmunology).
  • Understanding the MYC network is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To review the role of MYC in oncometabolism and oncoimmunology.
  • To elucidate how MYC regulates gene transcription and cellular metabolism in cancer.
  • To discuss therapeutic strategies targeting MYC-driven cancers.

Main Methods:

  • Literature review of existing knowledge on MYC's functions in cancer.
  • Exploration of multi-Omic approaches for characterizing the MYC network.
  • Analysis of MYC interactions with key factors like HIF-1α.

Main Results:

  • MYC significantly impacts glucose and glutamine metabolism.
  • MYC influences antigen presentation and metabolic reprogramming in regulatory T cells.
  • Specific MYC gene targets are involved in both metabolic and immune functions in cancer.

Conclusions:

  • MYC plays a pivotal role in shaping the tumor microenvironment through metabolic and immune modulation.
  • Targeting MYC offers a promising therapeutic avenue for various cancers.
  • Further research into the MYC network can reveal novel treatment strategies.
Keywords:
MYCcancerimmune evasionmetabolismoncoimmunology

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