The complex relationship between late-onset caloric restriction and synaptic plasticity in aged Wistar rats
Milica Prvulovic1, Srdjan Sokanovic1, Valentina Simeunovic1
1Department for Neurobiology, Institute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
IUBMB Life
|February 23, 2024
Summary
Caloric restriction (CR) in aging rats increased synaptic markers but did not improve cognitive function. Late-onset CR may not offer the same benefits as lifelong restriction for brain health.
Area of Science:
- Neuroscience
- Aging Research
- Nutritional Science
Background:
- Aging is associated with reduced spine density, synaptic markers, and efficiency, leading to cognitive decline.
- Caloric restriction (CR) is a promising intervention for ameliorating age-related cognitive decline and improving synaptic function.
Purpose of the Study:
- To investigate the effects of late-onset and short-term CR on synaptic plasticity in aging Wistar rats.
- To examine changes in key synaptic marker expression when CR is initiated at different life stages.
Main Methods:
- A long-term study was conducted on aging Wistar rats.
- Caloric restriction was implemented at various time points throughout the rats' lives.
- Expression levels of key presynaptic and postsynaptic markers were analyzed.
Main Results:
- Caloric restriction significantly increased the expression of both presynaptic and postsynaptic markers.
- Despite increased synaptic markers, previously reported behavioral changes suggest no cognitive benefit from CR.
Conclusions:
- The observed increase in synaptic markers due to late-onset CR in aging rats may not translate to improved cognitive function.
- The timing of CR initiation is critical, with late-onset CR potentially yielding different outcomes compared to lifelong CR.
