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Updated: Jul 2, 2025

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

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Massive transfusion in trauma.

Heiko Lier1, Björn Hossfeld2

  • 1Department of Anesthesiology and Intensive Care Medicine, University of Cologne, Faculty of Medicine, and University Hospital Cologne.

Current Opinion in Anaesthesiology
|February 23, 2024
PubMed
Summary
This summary is machine-generated.

Severe trauma necessitates massive transfusion protocols. Early hemorrhage control, coagulopathy treatment, and component therapy are crucial for managing traumatic hemorrhage shock.

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Area of Science:

  • Emergency Medicine
  • Trauma Surgery
  • Critical Care

Background:

  • Traumatic hemorrhage shock requires prompt intervention, often involving massive transfusion.
  • Lack of standardized international definitions for traumatic hemorrhage shock and massive transfusion complicates treatment protocols.

Approach:

  • Review of current literature on recommended treatment approaches for traumatic hemorrhage shock.
  • Focus on early diagnosis and management of trauma-induced coagulopathy.
  • Emphasis on timely substitution of deficiencies using laboratory and viscoelastic tests.

Key Points:

  • Massive transfusion is defined as 3-4 packed red blood cells within 1 hour in current literature.
  • Early identification and treatment of trauma-induced coagulopathy are essential.
  • Standardized laboratory and viscoelastic tests guide deficiency substitution.

Conclusions:

  • Massive transfusion protocols facilitate immediate therapy initiation.
  • Hemorrhage control via hemostatic dressings and tourniquets is vital.
  • Correction of metabolic derangements, along with component therapy (tranexamic acid, fibrinogen, RBCs, plasma, platelets) guided by viscoelastic assays and blood gas analysis, is recommended.
  • Whole blood is a viable alternative; additional factors (prothrombin complex, factor XIII, desmopressin) may be needed.