Lymphangiogenesis: A new strategy for heart disease treatment (Review)

Area of Science:

• Cardiovascular Science
• Lymphatic Biology
• Integrative Medicine

Background:

• Heart disease is a leading cause of global mortality, necessitating novel therapeutic strategies.
• The lymphatic vasculature is vital for cardiovascular homeostasis, regulating fluid balance and immune cell transport.
• Impaired cardiac lymphangiogenesis is implicated in various cardiovascular pathologies.

Approach:

• A scientometric analysis identified lymphangiogenesis as a key research area in cardiovascular disease.
• This review synthesizes current knowledge on mechanisms of impaired cardiac lymphangiogenesis.
• Investigated therapeutic strategies to enhance lymphangiogenesis for cardiovascular disease management.

Key Points:

• Dysfunctional cardiac lymphatics contribute to cardiovascular disease progression.
• Strategies to promote lymphangiogenesis offer potential therapeutic benefits for heart conditions.
• Traditional Chinese Medicine (TCM) demonstrates a significant impact on lymphangiogenesis.

Conclusions:

• Enhancing lymphangiogenesis is a promising avenue for treating cardiovascular diseases.
• TCM may offer a novel approach to improving cardiovascular health by targeting lymphangiogenesis.
• Further research is warranted to establish a clinical basis for TCM in cardiovascular therapeutics.