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  9. Predictive And Prognostic Markers
  11. Ck7+/ck20+/cdx2+ Mucinous Carcinoma, Arising In A Mature Cystic Teratoma Of Ovary, Presenting With Disseminated Metastasis And Pseudomyxoma Peritonei

CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei

Amit K Adhya1, Abhitesh Singh2, Dillip K Muduly2

  • 1Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Indian Journal of Pathology & Microbiology
|February 23, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Mucinous carcinoma in ovarian dermoid tumors is rare. This case highlights unusual CK7 positivity, pseudomyxoma peritonei, and lung metastasis, complicating diagnosis.

Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Gastroenterology

Background:

  • Mucinous carcinomas within ovarian dermoid tumors are infrequently reported.
  • These neoplasms often mimic appendiceal or lower gastrointestinal tract carcinomas with a CK7-/CK20+ immunophenotype.
  • Distinguishing these rare ovarian tumors from metastatic disease can be challenging.

Purpose of the Study:

  • To report a rare case of well-differentiated mucinous carcinoma arising in a mature cystic teratoma.
  • To highlight unusual morphological and immunohistochemical findings in this specific case.
  • To discuss the diagnostic implications of these atypical features.

Main Methods:

  • Histopathological examination of the ovarian tumor.
  • Immunohistochemical analysis including CK7, CK20, and CDX2.

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  • Review of relevant literature on ovarian mucinous neoplasms and teratomas.

    • Main Results:

    • The mucinous carcinoma exhibited diverse patterns: cystadenoma-like, borderline, villous adenoma-like, and invasive areas.
    • Unusual findings included diffuse CK7 positivity, pseudomyxoma peritonei, and pulmonary metastasis.
    • The tumor displayed a CK7+/CK20+/CDX2+ immunoprofile.

    Conclusions:

    • Ovarian teratoma-associated mucinous neoplasms can present with complex immunophenotypes (CK7+/CK20+/CDX2+).
    • These features can render them immunohistochemically indistinguishable from primary ovarian or metastatic lower GI mucinous carcinomas.
    • Careful clinicopathological correlation is crucial for accurate diagnosis and management.