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Updated: Jul 2, 2025
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
12.9K
Practical Lessons on Antimicrobial Therapy for Critically Ill Patients
Rachael Cusack1, Elizabeth Little1, Ignacio Martin-Loeches1,2
1Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James' Hospital, D08 NHY1 Dublin, Ireland.
Antibiotics (Basel, Switzerland)
|February 23, 2024
Summary
Sepsis remains a critical threat, causing high mortality and costs. This review details strategies to reduce sepsis incidence and impact in intensive care through infection control and antimicrobial stewardship.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Public Health
Background:
- Sepsis presents a significant global health burden with high mortality and morbidity.
- Rising healthcare costs associated with sepsis impact survivors annually.
- Antimicrobial resistance exacerbates the challenge of treating sepsis effectively.
Purpose of the Study:
- To review targeted measures for reducing sepsis incidence and impact in intensive care units (ICUs).
- To discuss strategies for preventing nosocomial infections and pathogen colonization.
- To highlight the importance of antimicrobial stewardship and innovative treatments.
Main Methods:
- Narrative review of current literature on sepsis management in intensive care.
- Discussion of infection control measures, including prevention of colonization.
- Analysis of antimicrobial stewardship, de-escalation, and emerging treatment modalities.
Main Results:
- Effective sepsis management requires reducing nosocomial infections and pathogen colonization.
- Antimicrobial stewardship is crucial due to rising bacterial resistance.
- Tailoring treatments to disease endotypes and exploring novel delivery systems are key.
Conclusions:
- Vigilant stewardship programs and robust infection control are essential for future intensive care.
- Addressing barriers to effective treatment of critically ill patients is paramount.
- Innovative technological solutions are vital for combating sepsis in ICUs.
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