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Cognitive Inflexibility Predicts Negative Symptoms Severity in Patients with First-Episode Psychosis: A 1-Year
Leonidas Mantonakis1, Pentagiotissa Stefanatou1, Antonis Tsionis1
1First Department of Psychiatry, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Brain Sciences
|February 23, 2024
Summary
Cognitive flexibility, measured by the Wisconsin Card Sorting Test, predicts future negative symptoms in first episode psychosis (FEP) patients. This finding aids in understanding psychosis progression and functional outcomes.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Negative symptoms and cognitive deficits significantly impact psychosis patients' functional outcomes.
- Limited research exists on predicting negative symptoms from cognitive deficits in first episode psychosis (FEP).
Purpose of the Study:
- To investigate the predictive capacity of cognitive deficits in FEP for subsequent negative symptomatology.
- To identify specific cognitive domains that predict negative symptom severity one year after FEP.
Main Methods:
- Retrospective longitudinal study of 80 drug-naive FEP patients.
- Cognitive tests and PANSS assessments at 1-month and 1-year post-admission.
- Multiple regression analysis controlling for confounding factors like DUP and prior symptom severity.
Main Results:
- Cognitive flexibility, assessed by Wisconsin Card Sorting Test (WCST) categories completed, significantly predicted 1-year negative symptom severity (p=0.01).
- This association remained significant after accounting for duration of untreated psychosis (DUP) and 1-month symptom levels.
Conclusions:
- Cognitive flexibility is a key predictor of negative symptom severity in FEP.
- Findings highlight the role of executive functions in psychosis progression and inform potential therapeutic targets.
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