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Surface Functionalization of Titanium-Based Implants with a Nanohydroxyapatite Layer and Its Impact on Osteoblasts: A
Karolina Homa1,2, Wojciech Zakrzewski3, Wojciech Dobrzyński4
1Niepubliczny Zakład Opieki Zdrowotnej Medident, Żeromskiego 2A, 43-230 Goczalkowice-Zdroj, Poland.
Journal of Functional Biomaterials
|February 23, 2024
Summary
Nanohydroxyapatite coatings on titanium implants enhance osseointegration and bone cell biocompatibility. Modified coatings further improve cell response and reduce bacterial activity, boosting implant stability and success rates.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Cell Biology
Background:
- Titanium and its alloys are widely used for dental and orthopedic implants.
- Osseointegration, the direct structural and functional connection between living bone and an implant surface, is crucial for implant success.
- Enhancing osseointegration and biocompatibility of implant surfaces remains a key challenge in regenerative medicine.
Purpose of the Study:
- To evaluate the influence of nanohydroxyapatite coatings on titanium implants regarding osseointegration and osteoblast cell line response.
- To investigate the effects of various nanohydroxyapatite coating modifications on bone and cell biocompatibility.
- To compare the performance of coated versus uncoated titanium implants.
Main Methods:
- A systematic review adhering to the PRISMA protocol was conducted.
- An electronic search of PubMed, Web of Science, and Scopus was performed in November 2023.
- Keywords used included (titanium) AND ((osteoblasts) and hydroxyapatite).
Main Results:
- Out of 1739 initial studies, 26 were included, with most focusing on nanohydroxyapatite coatings alone.
- Nine studies examined modified coatings (e.g., with chitosan, collagen, silver, gelatine).
- Nanohydroxyapatite coatings generally enhanced osseointegration and positively influenced cell lines, showing increased cellular spread and reduced bacterial activity with modifications.
Conclusions:
- Nanohydroxyapatite coatings show a propensity to improve osseointegration of titanium implants.
- Coating modifications can further enhance biocompatibility, cellular response, and antibacterial properties.
- These findings suggest nanohydroxyapatite-coated implants offer a potentially advantageous clinical option for improved implant stability and success rates.
