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Updated: Jul 2, 2025

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Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets

Dmitri Sisario1, Markus Spindler1, Katharina J Ermer1

  • 1Institute of Experimental Biomedicine-Chair I, University Hospital Würzburg, 97080 Würzburg, Germany.

Cells
|February 23, 2024
PubMed
Summary

FAM49b regulates platelet shape and migration by interacting with the WAVE-regulatory complex. Its absence enhances platelet spreading on fibrinogen but impairs it on micropatterns, requiring a functional WAVE complex for its inhibitory effects.

Keywords:
CYFIP1CYRI-BFAM49bRAC1WAVEactinlamellipodiamigrationplateletsspreading

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