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Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Additive Manufacturing Applications in Biosensors Technologies.

Abraham Abbey Paul1, Adedamola D Aladese2, Robert S Marks1,3

  • 1Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.

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|February 23, 2024
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) printing, or additive manufacturing, offers new ways to create advanced biosensors. This review explores 3D printing materials and methods for developing innovative biosensor technologies.

Keywords:
3D (bio)printingadditive manufacturingbioinksbiosensorspolymers

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Area of Science:

  • Biotechnology
  • Materials Science
  • Engineering

Background:

  • Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a powerful fabrication tool for complex functional materials.
  • While AM has advanced tissue engineering and therapeutics, its potential in sensor and biosensor development remains largely untapped.
  • Integrating biological functionalities into 3D scaffolds requires novel printing materials and printers.

Purpose of the Study:

  • To review the applications of additive manufacturing in biosensor technologies.
  • To emphasize extrusion-based 3D printing modalities for biosensor fabrication.
  • To explore the use of various biomaterials in creating 3D-printed biosensors.

Main Methods:

  • Review of existing literature on 3D printing and biosensor development.
  • Focus on extrusion-based additive manufacturing techniques.
  • Analysis of natural, synthetic, and composite biomaterials for 3D-printed soft hydrogels.
  • Examination of methods for incorporating sensing molecules during fabrication.

Main Results:

  • Additive manufacturing enables precise fabrication of complex biosensor geometries.
  • Extrusion-based 3D printing is a key modality for developing biosensors.
  • Natural, synthetic, and composite biomaterials can be utilized as 3D-printed soft hydrogels for biosensing.
  • Various strategies exist for introducing sensing molecules during the 3D printing process.

Conclusions:

  • Additive manufacturing holds significant promise for advancing biosensor technology.
  • Further innovation in printing materials and techniques will expand biotechnological applications.
  • The integration of biological functionalities into 3D-printed scaffolds is crucial for future biosensor development.