Responses of cochlear nucleus units to electrical stimulation through a cochlear prosthesis: channel interaction

The responses of 39 single units in the ventral cochlear nucleus of acute anesthetized guinea-pigs were studied with continuous electrical stimuli presented through a dual-channel implant in the scala tympani. Implants had four electrodes placed along the axis of the cochlea with 1 mm separations. With a specific pair (either apical or basal) of stimulating electrodes, about half of the units responded when current was flowing apically, while the rest responded to current in the opposite direction. No obvious relation existed between the effective polarity of the basal and apical pairs of electrodes. Two response types were observed while stimulating through both pairs simultaneously. Seventy-nine percent of the units responded to the sum of the current waveforms presented through the two pairs. Twenty-one percent responded to the difference between the waveforms. Both types of responses were observed for suprathreshold as well as for some intensities of stimulation that alone were subthreshold. The type of response was not dependent on the absolute threshold or threshold difference between the two pairs. For equal peak-intensities of stimuli, two-channel stimulation evoked larger responses than single-channel stimulation, provided the two channels were in their effective polarities. Responses to dual-channel stimulation were consistently larger than the summed responses to the two individual single-channel stimuli. The observed responses to the dual-channel stimulation indicate that the adequate stimulus was determined by the linear combination of fields produced by the individual channels in the vicinity of the stimulating electrodes before the auditory nerve is stimulated, and that excitation takes place in a spatially restricted area of the auditory nerve.