Decrease in Mortality after the Implementation of a Hospital Model to Improve Performance in Sepsis Care: Princess...

Area of Science:

• Critical Care Medicine
• Infectious Diseases
• Hospital Management

Background:

• Sepsis is a life-threatening condition where early diagnosis and treatment are critical for patient survival.
• High sepsis mortality rates necessitate structured care protocols, as recommended by Surviving Sepsis Campaign guidelines.
• Developing effective hospital-based sepsis management programs is essential for improving patient outcomes.

Purpose of the Study:

• To evaluate the impact of the Princess Sepsis Code, a hospital-wide sepsis care model, on patient mortality.
• To identify key factors associated with mortality in sepsis patients.
• To assess the effectiveness of a structured sepsis intervention program.

Main Methods:

• A retrospective study analyzed clinical, epidemiological, and outcome data from 2676 sepsis patients diagnosed between 2015 and 2022.
• The study compared sepsis mortality rates before and after the implementation of the Princess Sepsis Code.
• Multivariate analysis identified independent predictors of mortality.

Main Results:

• Sepsis mortality decreased from 24% in 2015 to 17% in 2022 following the implementation of the Princess Sepsis Code.
• Abdominal sepsis was the most frequent focus; 32% of patients required intensive care unit admission.
• Independent predictors of mortality included advanced age, elevated respiratory rate, altered consciousness, high serum lactate, and renal impairment.

Conclusions:

• The Princess Sepsis Code care model is effective in reducing mortality for patients with sepsis and septic shock.
• Early identification and management of sepsis are crucial for improving survival rates.
• Specific patient factors and sepsis characteristics significantly influence mortality risk.