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Decrease in Mortality after the Implementation of a Hospital Model to Improve Performance in Sepsis Care: Princess

Rosa Méndez1, Angels Figuerola2, Fernando Ramasco1

  • 1Department of Anaesthesiology and Surgical Intensive Care, Hospital Universitario de La Princesa, Diego de León 62, 28006 Madrid, Spain.

Journal of Personalized Medicine
|February 23, 2024
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Summary
This summary is machine-generated.

Implementing the Princess Sepsis Code hospital model significantly reduced sepsis mortality. This sepsis care program led to a decrease in patient deaths from 24% in 2015 to 17% in 2022.

Keywords:
intensive care unitsmortalityqSOFAsepsissepsis codeseptic shock

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Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Hospital Management

Background:

  • Sepsis is a life-threatening condition where early diagnosis and treatment are critical for patient survival.
  • High sepsis mortality rates necessitate structured care protocols, as recommended by Surviving Sepsis Campaign guidelines.
  • Developing effective hospital-based sepsis management programs is essential for improving patient outcomes.

Purpose of the Study:

  • To evaluate the impact of the Princess Sepsis Code, a hospital-wide sepsis care model, on patient mortality.
  • To identify key factors associated with mortality in sepsis patients.
  • To assess the effectiveness of a structured sepsis intervention program.

Main Methods:

  • A retrospective study analyzed clinical, epidemiological, and outcome data from 2676 sepsis patients diagnosed between 2015 and 2022.
  • The study compared sepsis mortality rates before and after the implementation of the Princess Sepsis Code.
  • Multivariate analysis identified independent predictors of mortality.

Main Results:

  • Sepsis mortality decreased from 24% in 2015 to 17% in 2022 following the implementation of the Princess Sepsis Code.
  • Abdominal sepsis was the most frequent focus; 32% of patients required intensive care unit admission.
  • Independent predictors of mortality included advanced age, elevated respiratory rate, altered consciousness, high serum lactate, and renal impairment.

Conclusions:

  • The Princess Sepsis Code care model is effective in reducing mortality for patients with sepsis and septic shock.
  • Early identification and management of sepsis are crucial for improving survival rates.
  • Specific patient factors and sepsis characteristics significantly influence mortality risk.