Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infertility in Males01:23

Infertility in Males

264
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
264
Spermatogenesis01:41

Spermatogenesis

102.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.5K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

416
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
416
Menopause01:28

Menopause

161
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
161
Infertility in Females01:28

Infertility in Females

293
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
293
Sperm Transport01:15

Sperm Transport

813
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
813

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal exposure to the fungicide flutolanil induces developmental and hepatic toxicity in pregnant rats and their fetuses: Insights from In Vivo and In Silico studies and the protective role of Chlorella vulgaris.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same author

Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology.

Medicina (Kaunas, Lithuania)·2025
Same author

Use of time-lapse technology and artificial intelligence in the embryology laboratory: an updated review.

JBRA assisted reproduction·2025
Same author

The importance of education, training and continuous performance monitoring to ART professionals, particularly embryologists.

Human fertility (Cambridge, England)·2025
Same author

The Oxidative Stress of Human Sperm Cryopreservation.

Antioxidants (Basel, Switzerland)·2025
Same author

Morphometric Blastocyst Assessment: A Retrospective Study Examining the Relationship Between Blastocyst Diameter and Area and Pregnancy Outcomes in Assisted Reproduction Technology Cycles.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Jul 2, 2025

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

2.4K

Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative

Romualdo Sciorio1, Luca Tramontano2, Mohammed Adel3

  • 1Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman-Mother-Child, Lausanne University Hospital, 1011 Lausanne, Switzerland.

Journal of Personalized Medicine
|February 23, 2024
PubMed
Summary

Sperm quality has declined over decades, potentially due to environmental toxins like endocrine-disrupting chemicals (EDCs). This review examines EDC effects on testicular function and sperm parameters, impacting male fertility.

Keywords:
environmental toxins: bisphenol A and phthalateslifestylemale infertilityobesityoxidative stresssperm parameters

More Related Videos

Sperm Collection of Differential Quality Using Density Gradient Centrifugation
03:28

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

19.7K
Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
08:32

Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function

Published on: June 23, 2023

1.9K

Related Experiment Videos

Last Updated: Jul 2, 2025

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

2.4K
Sperm Collection of Differential Quality Using Density Gradient Centrifugation
03:28

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

19.7K
Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
08:32

Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function

Published on: June 23, 2023

1.9K

Area of Science:

  • Reproductive Biology
  • Environmental Health
  • Toxicology

Background:

  • Semen quality is crucial for fertility, with established declines in sperm parameters over the past 40 years.
  • Current WHO guidelines for normal sperm counts (16 million/mL) are debated, as reduced fecundity is observed below 30 million/mL.
  • Factors like maternal smoking, poor diet, obesity, and environmental toxins are implicated in declining sperm quality.

Purpose of the Study:

  • To review the impact of endocrine-disrupting chemicals (EDCs) on testicular function and spermatogenesis.
  • To summarize evidence on decreased sperm quality and its potential consequences.

Main Methods:

  • This is a narrative review, synthesizing existing scientific literature.
  • The review focuses on studies investigating environmental exposures and their effects on male reproductive health.

Main Results:

  • Exposure to EDCs, including pesticides, phthalates, and heavy metals, from prenatal life through adulthood is a probable cause for reduced sperm parameters.
  • Evidence suggests a link between environmental factors and the observed decline in semen quality.

Conclusions:

  • Endocrine-disrupting chemicals pose a significant threat to male reproductive health by impairing testicular function and spermatogenesis.
  • Further research is needed to fully elucidate the mechanisms and consequences of EDC exposure on sperm quality and male fertility.