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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
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Transcytosis of IgG01:15

Transcytosis of IgG

2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Related Experiment Video

Updated: Jul 2, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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IgD+IgM- B Cells in Common Variable Immunodeficiency.

Taissa de M Kasahara1, Sudhir Gupta2

  • 1Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.

Pathogens (Basel, Switzerland)
|February 23, 2024
PubMed
Summary

Common variable immunodeficiency (CVID) involves immune dysregulation. IgD+ memory B cells may contribute to allergic conditions in CVID patients, while anergic IgD+ B cells appear unaffected.

Keywords:
B cellCVIDIgDrespiratory allergic diseasestolerance

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Area of Science:

  • Immunology
  • B cell biology

Background:

  • Common variable immunodeficiency (CVID) is a primary hypogammaglobulinemia in adults, frequently causing infections and autoimmune complications.
  • Immune dysregulation mechanisms in CVID are not fully understood.
  • Immunoglobulin D (IgD) plays a role in B cell tolerance and mucosal immunity.

Purpose of the Study:

  • To investigate the frequency and function of IgD-expressing B cells in CVID patients.
  • To explore the potential role of IgD+ B cells in CVID-related autoimmune diseases and allergic conditions.

Main Methods:

  • Flow cytometry was used to analyze IgD+ naive and memory B cell populations.
  • Proliferative responses of anergic IgD+IgM-CD27- B cells were assessed.
  • CVID patients with and without autoimmune disease were compared to healthy controls.

Main Results:

  • No significant differences were found in anergic IgD+IgM-CD27- B cells between CVID patients and controls.
  • A higher percentage of IgD+IgM- memory B cells was observed specifically in CVID patients with allergic rhinitis or asthma.

Conclusions:

  • Anergic IgD+IgM-CD27- B cells do not appear to be compromised in the studied CVID cohort.
  • IgD+IgM- memory B cells may be implicated in the immunopathogenesis of allergic rhinitis and asthma in CVID patients.
  • Further research is necessary to elucidate the precise role of IgD+IgM- memory B cells in CVID-associated allergies.