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Two Cases of Vancomycin-Induced Neutropenia
Kirsten Ganaja1, Sarah Scoular2, Staci Hemmer2
1Dignity Health Marian Regional Medical Center, Santa Maria, CA 93454, USA.
Pharmacy (Basel, Switzerland)
|February 23, 2024
Summary
Vancomycin-induced neutropenia is a rare adverse drug reaction. Two cases highlight the need for further research into its incidence and risk factors.
Area of Science:
- Pharmacology
- Hematology
- Infectious Diseases
Background:
- Vancomycin-induced neutropenia incidence is estimated at 2-8% in hospitalized patients.
- Limited data exists due to small observational studies and varying patient characteristics.
- Generalized conclusions are difficult to ascertain from current literature.
Observation:
- Two cases of vancomycin-induced neutropenia are presented.
- A 50-year-old male with a gluteal abscess and a 51-year-old female with lumbar osteomyelitis developed neutropenia.
- Neutropenia resolved within 2 days of vancomycin discontinuation in both patients.
Findings:
- Vancomycin-induced neutropenia is considered uncommon.
- Two cases occurred within a 3-month period at the same facility.
- Prolonged vancomycin exposure is a likely cause.
Implications:
- Further studies are needed to determine the true incidence of vancomycin-induced neutropenia.
- Identifying risk factors for this adverse drug reaction is crucial.
- Enhanced monitoring may be warranted in patients receiving prolonged vancomycin therapy.
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