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Skeletal Muscle Gender Dimorphism from Proteomics

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A Decrease in Branched-Chain Amino Acids after a Competitive Male Professional Volleyball Game-A Metabolomic-Based

Taillan Martins Oliveira¹, Tathiany Jéssica Ferreira¹, Paula Albuquerque Penna Franca¹

¹Laboratory of Food Development for Special Health Purpose and Education (DAFEE), Nutrition Institute Josué de Castro (INJC), Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Rio de Janeiro, Brazil.

|February 23, 2024

Summary

A single volleyball game altered athletes' metabolomic profiles, decreasing essential amino acids like leucine, valine, and isoleucine. These changes may stem from diet and energy demands, impacting athletic performance.

Keywords:

biomarkers exercise metabolomics nuclear magnetic resonance recovery

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Area of Science:

Sports Science
Metabolomics
Exercise Physiology

Background:

Professional volleyball is a high-intensity sport demanding significant metabolic and physical effort.
Understanding the physiological impact of a single game is crucial for optimizing athlete recovery and performance.
Preseason training phases require careful monitoring of athletes' biochemical and metabolic responses.

Purpose of the Study:

To investigate the biochemical and metabolomic changes in professional volleyball players following a single competitive game.
To identify specific metabolites affected by the physical demands of a volleyball match.
To provide insights for developing targeted nutritional and recovery strategies for athletes.

Main Methods:

Cross-sectional study involving 13 male Brazilian professional volleyball players.
Evaluation of food intake, body composition, heart rate, and physical movement variables.
Non-target metabolomic analysis of serum samples using 500 MHz Nuclear Magnetic Resonance (NMR).

Main Results:

No significant differences were observed in standard biochemical indicators post-game (p > 0.05).
Metabolomic analysis revealed decreased levels of key metabolites including beta-hydroxybutyrate, arginine/lysine, and essential amino acids (isoleucine, leucine, valine).
Increased levels of formic acid, histidine, hypoxanthine, and tyrosine were noted, alongside decreased low-density and very low-density lipoprotein levels.

Conclusions:

A single volleyball game induced significant negative variations in essential amino acid profiles.
These metabolic shifts may be linked to dietary intake and energy utilization, potentially involving skeletal muscle amino acid oxidation.
Findings highlight the need for tailored metabolic compensation strategies to support athlete recovery and performance.