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Updated: Jun 14, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

Fish By-Product Collagen Extraction Using Different Methods and Their Application.

Sunita Gaikwad¹, Mi Jeong Kim^1,2

¹Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon 51140, Republic of Korea.

|February 23, 2024

Summary

This summary is machine-generated.

Fish processing byproducts, rich in collagen, are often wasted. This review details extraction methods and diverse applications for fish collagen, unlocking its potential.

Keywords:

biomedical source collagen extraction fish byproducts food additive

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Area of Science:

Biotechnology
Marine Science
Biochemistry

Background:

Fishery processing generates substantial byproducts (heads, skins, viscera), with up to 75% often discarded.
Current utilization of fish byproducts is limited to low-value products and fish oil, representing a significant loss of valuable biomaterials.

Purpose of the Study:

To comprehensively review collagen extraction techniques from fish byproducts.
To investigate the influence of various extraction parameters on collagen yield.
To explore the diverse applications of fish-derived collagen in biomedical, food, and cosmetic industries.

Main Methods:

Review of established collagen extraction methods: acid-soluble collagen (ASC), enzyme-soluble collagen (ESC).
Analysis of advanced extraction techniques: ultrasound-assisted extraction, deep eutectic solvent (DES) extraction, and supercritical fluid extraction (SFE).
Examination of critical extraction parameters: time, temperature, solid-to-liquid ratio, and solvent/enzyme concentration.

Main Results:

Multiple extraction methods demonstrate varying efficiencies in isolating collagen from fish byproducts.
Optimization of extraction parameters significantly impacts collagen yield and quality.
Fish collagen exhibits promising potential across biomedical, food, and cosmetic applications.

Conclusions:

Fish byproducts represent a valuable, underutilized source of collagen.
Understanding extraction parameters is crucial for maximizing collagen recovery and quality.
Further research into fish collagen applications can drive innovation in various industries.