Synthesis of Bioactive Nickel Nanoparticles Using Bacterial Strains from an Antarctic Consortium
Joseph Amruthraj Nagoth1, Maria Sindhura John1,2, Kesava Priyan Ramasamy1,3
1School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
Marine Drugs
|February 23, 2024
Summary
Marine bacteria synthesized nickel nanoparticles (NiSNPs) with significant antimicrobial activity. These NiSNPs show potential for developing new treatments against infectious diseases.
Area of Science:
- Marine microbiology and nanotechnology.
- Biomaterials synthesis and characterization.
Background:
- Marine microorganisms are a valuable source of novel bioactive molecules.
- Antarctic marine bacteria present unique biochemical properties for biosynthesis.
Purpose of the Study:
- To synthesize nickel nanoparticles (NiSNPs) using five Antarctic marine bacterial strains.
- To characterize the synthesized NiSNPs and evaluate their antimicrobial properties.
Main Methods:
- Biosynthesis of NiSNPs using bacterial strains: Marinomonas sp. ef1, Rhodococcus sp. ef1, Pseudomonas sp. ef1, Brevundimonas sp. ef1, and Bacillus sp. ef1.
- Characterization techniques: UV-vis spectroscopy, DLS, TEM, XRD, and FTIR.
- Antimicrobial activity assays.
Main Results:
- NiSNPs exhibited surface plasmon resonance (SPR) between 374-422 nm.
- Characterization confirmed polycrystalline NiSNPs (40-45 nm) with a face-centered cubic lattice.
- TEM revealed spherical/rod-shaped NiSNPs (20-50 nm) with negative zeta potential.
- FTIR indicated binding of amino acids and proteins to NiSNPs.
- Synthesized NiSNPs demonstrated significant antimicrobial activity.
Conclusions:
- Antarctic marine bacteria can effectively synthesize NiSNPs.
- The characterized NiSNPs possess potent antimicrobial properties.
- NiSNPs hold promise for the development of novel therapeutic agents against infectious diseases.
