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Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
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Published on: January 2, 2013

Cerebrospinal fluid centrifuge analysis in primary amebic meningoencephalitis due to Naegleria fowleri

R L Benson, L Ansbacher, R E Hutchison

    Archives of Pathology & Laboratory Medicine
    |July 1, 1985
    PubMed

    Insights

    This report details the first known case of primary amebic meningoencephalitis caused by Naegleria fowleri in Missouri. Morphologic identification of amebas in cerebrospinal fluid is emphasized for diagnosis.

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Parasitology

    Background:

    • Primary amebic meningoencephalitis (PAM) is a rare and fatal infection of the central nervous system.
    • Naegleria fowleri is a free-living ameba responsible for PAM, typically found in warm freshwater environments.

    Observation:

    • This case represents the first documented occurrence of Naegleria fowleri infection in Missouri.
    • The patient presented with symptoms consistent with rapidly progressive meningoencephalitis.

    Findings:

    • Morphologic identification of degenerating amebas was successfully performed on a cerebrospinal fluid cytospin preparation.
    • Wright's stain proved effective in visualizing the amebic forms during the acute stage of the illness.

    Implications:

    • This case highlights the geographic expansion or increased recognition of Naegleria fowleri in new regions.
    • Early diagnostic methods, including microscopic examination of CSF, are crucial for timely identification and management of PAM.
    • Increased awareness among clinicians in Missouri regarding this rare but devastating infection is warranted.

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