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Related Experiment Videos

Infectious mononucleosis. Appendiceal lymphoid tissue involvement parallels characteristic lymph node changes.

A O'Brien, D S O'Briain

    Archives of Pathology & Laboratory Medicine
    |July 1, 1985
    PubMed
    Summary

    Acute abdominal pain in an 18-year-old was linked to infectious mononucleosis. The appendix showed changes similar to lymph nodes, suggesting this pattern predicts the infection.

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    Area of Science:

    • Gastroenterology
    • Pathology
    • Infectious Diseases

    Background:

    • Appendectomy and lymph node biopsy were performed for acute abdominal pain.
    • The patient was diagnosed with infectious mononucleosis.

    Observation:

    • The appendix exhibited significant lymphoid tissue hyperplasia.
    • Expansion of the lamina propria by immunoblasts, including Reed-Sternberg-like cells, was noted.
    • Reactive but inconspicuous germinal centers were present.

    Findings:

    • Appendiceal lymphoid tissue changes mimicked lymph node alterations seen in infectious mononucleosis.
    • This distinctive pattern is distinguishable from malignant lymphoma.
    • The findings suggest gut-associated lymphoid tissue involvement contributes to abdominal symptoms.

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    Implications:

    • Appendiceal and lymph node pathology can be predictive of infectious mononucleosis.
    • Understanding gut-associated lymphoid tissue involvement enhances diagnosis of abdominal pain in mononucleosis.
    • This case highlights the importance of considering infectious etiologies for acute abdominal pain.