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MicroRNAs in Male Fertility

Sedigheh Bahmyari1, Seyyed Hossein Khatami2, Sina Taghvimi3

  • 1Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

DNA and Cell Biology
|February 23, 2024
PubMed

Insights

Male infertility affects 50% of cases, impacting public health. MicroRNAs (miRNAs) show altered expression in infertile men, suggesting their potential as diagnostic and therapeutic biomarkers for male reproductive health.

Area of Science:

  • Reproductive Biology
  • Molecular Biology
  • Genetics

Background:

  • Male factor infertility is a significant global health issue, affecting approximately 50% of infertility cases.
  • Spermatogenesis can be disrupted by various factors, leading to abnormal sperm parameters (count, motility, morphology).
  • MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation across physiological and pathological processes.

Purpose of the Study:

  • To explore the role of microRNAs (miRNAs) in male infertility.
  • To investigate the potential of miRNAs as diagnostic and therapeutic indicators for male reproductive health disorders.

Main Methods:

  • Analysis of microRNA (miRNA) gene expression patterns in infertile men.
  • Review of existing research on miRNA regulation in spermatogenesis and male reproductive cells.

Main Results:

  • Differential expression of microRNA (miRNA) genes has been observed in infertile men compared to fertile controls.
  • MicroRNAs (miRNAs) are regulators of spermatogenesis at multiple stages and within various male reproductive cell types.

Conclusions:

  • MicroRNAs (miRNAs) demonstrate significant potential as biomarkers for diagnosing male infertility.
  • Targeting microRNAs (miRNAs) may offer novel therapeutic strategies for male reproductive diseases.
  • Further research is required to elucidate the precise regulatory mechanisms of microRNAs (miRNAs) in male reproduction.
Keywords:
male infertilitymiRNAsmolecular biologyreproductionspermatogenesis

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