Suboptimal capability of individual machine learning algorithms in modeling small-scale imbalanced clinical data of...

In recent years, artificial intelligence (AI) has shown promising applications in various scientific domains, including biochemical analysis research. However, the effectiveness of AI in modeling small-scale, imbalanced datasets remains an open question in such fields. This study explores the capabilities of eight basic AI algorithms, including ridge regression, logistic regression, random forest regression, and others, in modeling a small, imbalanced clinical dataset (total n = 387, class 0 = 27, class 1 = 360) related to the records of the biochemical blood tests from the patients with multiple wasp stings (MWS). Through rigorous evaluation using k-fold cross-validation and comprehensive scoring, we found that none of the models could effectively model the data. Even after fine-tuning the hyperparameters of the best-performing models, the results remained below acceptable thresholds. The study highlights the challenges of applying AI to small-scale datasets with imbalanced groups in biochemical or clinical research and emphasizes the need for novel algorithms tailored to small-scale data. The findings also call for further exploration into techniques such as transfer learning and data augmentation, and they underline the importance of understanding the minimum dataset scale required for effective AI modeling in biochemical contexts.