Formulation and characterization of glipizide solid dosage form with enhanced solubility
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View abstract on PubMed
Summary
This summary is machine-generated.This study enhanced glipizide solubility using solid dispersions with polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG). PVP-based formulations showed superior drug release and solubility compared to PEG, leading to optimized immediate-release tablets.
Area Of Science
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background
- Glipizide is a poorly water-soluble drug classified under BCS Class II.
- Enhancing the solubility and dissolution rate of such drugs is crucial for improving bioavailability.
- Solid dispersion technology offers a promising approach to overcome solubility challenges.
Purpose Of The Study
- To enhance the solubility and dissolution rate of glipizide.
- To prepare and characterize glipizide solid dispersions using polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG).
- To evaluate the effect of different drug-to-polymer ratios and polymer types on glipizide's pharmaceutical properties.
Main Methods
- Glipizide solid dispersions were prepared using the solvent evaporation method.
- Various drug-to-polymer ratios (1:1, 1:2, 1:3, 1:4) and polymers (PVP K30, PVP K90, PEG 6000) were employed.
- In-vitro dissolution studies were conducted at pH 6.8 and 37°C using USP type II apparatus.
- Solid-state characterization included FTIR, XRD, and DSC to assess drug-polymer interactions.
Main Results
- Solid dispersions significantly enhanced glipizide's solubility and dissolution rate compared to physical blends and the pure drug.
- Formulations with higher polymer concentrations demonstrated improved solubility.
- Polyvinyl pyrrolidone (PVP)-based solid dispersions exhibited more favorable drug release profiles than those with polyethylene glycol (PEG).
- Characterization studies confirmed the compatibility between glipizide and the polymers used.
Conclusions
- Solid dispersion technology effectively enhances the solubility and dissolution of poorly water-soluble glipizide.
- Polyvinyl pyrrolidone (PVP) is a suitable carrier for developing glipizide solid dispersions with improved release characteristics.
- Optimized solid dispersion formulations were successfully converted into immediate-release tablets meeting pharmacopoeial standards.
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