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Published on: August 9, 2022
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Formulation and characterization of glipizide solid dosage form with enhanced solubility.
Badriyah Shadid Alotaibi1, Muhammad Ahsan Khan2, Kaleem Ullah3
1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Plos One
|February 23, 2024
Summary
This study enhanced glipizide solubility using solid dispersions with polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG). PVP-based formulations showed superior drug release and solubility compared to PEG, leading to optimized immediate-release tablets.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Glipizide is a poorly water-soluble drug classified under BCS Class II.
- Enhancing the solubility and dissolution rate of such drugs is crucial for improving bioavailability.
- Solid dispersion technology offers a promising approach to overcome solubility challenges.
Purpose of the Study:
- To enhance the solubility and dissolution rate of glipizide.
- To prepare and characterize glipizide solid dispersions using polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG).
- To evaluate the effect of different drug-to-polymer ratios and polymer types on glipizide's pharmaceutical properties.
Main Methods:
- Glipizide solid dispersions were prepared using the solvent evaporation method.
- Various drug-to-polymer ratios (1:1, 1:2, 1:3, 1:4) and polymers (PVP K30, PVP K90, PEG 6000) were employed.
- In-vitro dissolution studies were conducted at pH 6.8 and 37°C using USP type II apparatus.
- Solid-state characterization included FTIR, XRD, and DSC to assess drug-polymer interactions.
Main Results:
- Solid dispersions significantly enhanced glipizide's solubility and dissolution rate compared to physical blends and the pure drug.
- Formulations with higher polymer concentrations demonstrated improved solubility.
- Polyvinyl pyrrolidone (PVP)-based solid dispersions exhibited more favorable drug release profiles than those with polyethylene glycol (PEG).
- Characterization studies confirmed the compatibility between glipizide and the polymers used.
Conclusions:
- Solid dispersion technology effectively enhances the solubility and dissolution of poorly water-soluble glipizide.
- Polyvinyl pyrrolidone (PVP) is a suitable carrier for developing glipizide solid dispersions with improved release characteristics.
- Optimized solid dispersion formulations were successfully converted into immediate-release tablets meeting pharmacopoeial standards.
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