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Phosphaturic mesenchymal tumor: Clinicopathological features with outcomes in 10 patients with review of literature
Vivek C Parameshwar1, Bharat Rekhi2, Ashwini Duggad2
1Centre for Oncopathology, Mumbai, Maharashtra, India.
Indian Journal of Pathology & Microbiology
|February 23, 2024
Summary
Phosphaturic mesenchymal tumors (PMTs) are rare, benign neoplasms causing debilitating symptoms. Complete surgical resection offers a curative solution, relieving patients of their symptoms with no recurrence.
Area of Science:
- Oncology
- Pathology
- Endocrinology
Background:
- Phosphaturic mesenchymal tumors (PMTs) are rare neoplasms causing debilitating, non-specific symptoms.
- Timely diagnosis and surgical excision are crucial for patient recovery.
Purpose of the Study:
- To evaluate the clinical and histopathological features of 10 PMTs.
- To assess the clinical outcomes following diagnosis and treatment.
Main Methods:
- Retrospective study of 10 PMTs diagnosed between January 2013 and July 2022.
- Analysis of clinical presentation, histopathology, and biochemical markers (serum calcium, phosphorus, FGF23).
Main Results:
- Average age at diagnosis was 40 years (M:F ratio 4:1).
- Clinical features included lumps, bone pain, and mobility issues.
- Biochemical findings revealed low serum phosphorus and elevated FGF23.
- Histopathology showed a hemangiopericytomatous pattern with characteristic "grungy calcifications" in most cases.
- Five patients with follow-up experienced complete symptom resolution post-resection with no recurrence.
Conclusions:
- PMTs are benign neoplasms diagnosed through clinicoradiological, biochemical, and histopathological correlation.
- Surgical resection provides complete relief from debilitating symptoms.
- Accurate and prompt diagnosis is essential for effective patient management.
