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Prognostic significance of aortic valve calcification in relation to coronary artery calcification for cardiovascular
Han Wen1,2, Rihua Huang1,2, Xinghao Xu1,2
1Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, China.
European Journal of Preventive Cardiology
|February 23, 2024
Summary
The presence of both aortic valve calcification (AVC) and coronary artery calcification (CAC) significantly increases cardiovascular disease (CVD) risk, indicating a synergistic interaction. Managing both calcifications may improve patient outcomes.
Area of Science:
- Cardiology
- Atherosclerosis Research
- Public Health
Background:
- Coronary artery calcification (CAC) and aortic valve calcification (AVC) are linked to cardiovascular diseases (CVDs).
- Limited data exists on the prognostic significance of combined cardiovascular calcifications.
Purpose of the Study:
- To investigate the interaction between AVC and CAC for major adverse cardiovascular events.
- To assess the combined predictive value of AVC and CAC on CVD outcomes.
Main Methods:
- Analysis of 6695 participants from the Multi-Ethnic Study of Atherosclerosis.
- Categorization into four groups: no calcification, AVC only, CAC only, or both AVC and CAC.
- Utilized Cox regression, Kaplan-Meier analysis, and pooled cohort equations (PCEs) to evaluate CVD outcomes and interactions.
Main Results:
- Participants with both AVC and CAC had a significantly increased risk of CVD (HR = 3.43) and all-cause death.
- The combined risk from both AVC and CAC exceeded the sum of individual risks, demonstrating a synergistic interaction (P < 0.001).
- Adding AVC and CAC improved the predictive value of PCEs for CVD events.
Conclusions:
- A synergistic interaction exists between AVC and CAC in predicting cardiovascular events.
- Simultaneous management of both AVC and CAC may offer significant co-benefits for preventing adverse outcomes.
- This highlights the importance of assessing multiple calcification sites for comprehensive CVD risk stratification.
