Related Experiment Video

Updated: May 12, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

15.0K

Risk Factors for Massive Cerebral Infarction in Pediatric Patients With Moyamoya Disease

Fangbin Hao1, Gan Gao1, Qingbao Guo1

  • 1Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China; Chinese PLA Medical School, Beijing, China; Department of Neurosurgery, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.

Pediatric Neurology
|February 23, 2024
PubMed
Abstract

Insights

Family history, higher MRA scores, poor collateral circulation, and RNF213 variations increase the risk of massive cerebral infarction (MCI) in children with moyamoya disease (MMD). Early identification of these risk factors aids timely intervention.

Area of Science:

  • Neurology
  • Pediatric Medicine
  • Genetics

Background:

  • Moyamoya disease (MMD) is a rare cerebrovascular disorder.
  • Pediatric MMD patients face risks of preoperative massive cerebral infarction (MCI).
  • Identifying MCI risk factors is crucial for early intervention.

Purpose of the Study:

  • To explore risk factors for preoperative MCI in pediatric moyamoya disease patients.
  • To develop a predictive model for MCI in this population.

Main Methods:

  • Retrospective analysis of 308 pediatric MMD patients (2017-2022).
  • Logistic regression and nomogram construction to identify MCI predictors.
  • Receiver operating characteristic (ROC) curve analysis for risk factor assessment.

Main Results:

  • 36 pediatric MMD patients developed MCI.
  • Key risk factors identified: family history, higher MRA score, lower collateral circulation score, and RNF213 p.R4810K variations.
  • A nomogram and integrated ROC model showed high predictive accuracy (85.11%).

Conclusions:

  • Family history, elevated MRA score, reduced collateral circulation, and RNF213 variations are significant MCI risk factors in pediatric MMD.
  • The developed predictive model demonstrates superior efficacy for early risk identification.
  • Timely intervention based on predictive models can improve patient outcomes.
Keywords:
Cerebrovascular disordersChildrenMassive cerebral infarctionMoyamoya diseaseNatural courseRisk factors

More Related Videos

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

21.6K
A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.8K

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...