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Updated: Jul 2, 2025

Microfluidic Applications for Disposable Diagnostics
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Microfluidics as diagnostic tools.

Avanthika Satish Kumar1, Sneha Venkatesalu1, Shanmugapriya Dilliyappan1

  • 1Department of Biotechnology, Dr. M.G.R. Educational and Research Institute, Chennai, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 23, 2024
PubMed
Summary

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This summary is machine-generated.

Microfluidic chip technology enhances disease diagnosis precision and speed. This biomedical engineering advancement offers point-of-care solutions for autoimmune, cardiovascular, infectious, and neurodegenerative diseases.

Area of Science:

  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • Disease management relies heavily on diagnostic procedures' precision, speed, and ease.
  • Biomedical engineering innovations, particularly microfluidic chip technology, are transforming healthcare and improving patient outcomes.
  • Microfluidics enables miniaturization and integration of laboratory functions onto a single chip for point-of-care diagnostics.

Purpose of the Study:

  • To provide a comprehensive review of microfluidic chip technology's utility in diagnosing various diseases.
  • To highlight the application of microfluidics in diagnosing autoimmune disorders, cardiovascular diseases (CVDs), infectious diseases, and neurodegenerative conditions.
  • To discuss detection technologies for precise CVD diagnosis using microfluidics.

Main Methods:

  • Review of existing literature on microfluidic chip applications in disease diagnosis.
Keywords:
DiagnosisHuman diseaseMicrofluidic chipPoint-of-carePrecision

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  • Inclusion of global health threats like rheumatoid arthritis, diabetes, tuberculosis, COVID-19, Alzheimer's, and multiple sclerosis.
  • Discussion of electrochemical, electrical, optical, and acoustic detection methods for CVD diagnosis.

    • Main Results:

    • Microfluidic platforms offer "one flow - one solution" systems for integrated diagnostics.
    • These technologies enable "point-of-care" diagnostics through miniaturization.
    • Advancements facilitate precise and early disease diagnosis.

    Conclusions:

    • Microfluidic chip technology is revolutionizing disease diagnosis across a spectrum of conditions.
    • The integration of multiple lab functions onto a single chip enhances diagnostic capabilities.
    • Early and precise diagnosis is significantly improved by microfluidics-based advancements.